Tests for the best
Advanced Product Guide
Press
News
Portfolio Update
FAQ
Information & Services
Contact
Newsletter
Information & Services
Downloads
Company Information
Flyers
Discovery Lead Optimisation Services
Pharmacokinetics /Pharmacodynamics - Bioanalytics
Target Based Bioassays in vitro and in vivo
Test sequence
Physico-chemical parameters
Aqueous solubility
Chemical stability (specific assay conditions)
Lipophilicity by CHI
ADMET
Metabolic stability determination in vitro (various species)
Microsomes (Phase I and/or glucuronidation, various species)
Hepatocytes (various species)
Metabolite identification and characterisation (in vitro or ex vivo)
P450 profiling
Rapid screen (recombinantly expressed single P450 enzymes)
Probe substrate approach with microsomes (meets FDA guidelines)
P450 inhibition
Evaluation of direct and metabolism- dependent inhibition of Cytochrome P450 enzymes
Rapid screen (recombinantly expressed single P450 enzymes)
Probe substrate approach with liver microsomes (meets FDA guidelines)
P450 induction
Metabolism assay in HepaRG cell line
Plasma, serum or blood stability
Permeability screen in vitro on artificial membranes
PAMPA (prediction of intestinal absorption)
BBB (prediction of CNS penetration)
Permeability screen in vitro on Caco2 cell monolayers
Pgp affinity (bidirectional transport in Caco2)
Pgp inhibition (ATPase assay)
Plasma or serum protein binding
Determination of K
d
for HSA and AGP
In vitro cytotoxicity
Histamine release ex vivo in rat mastocytes
In vivo Pharmacokinetics
Cassette dosing
Cassette analysing
Single in vivo PK
Metabolism and excretion
Biomarkers and immunochemistry
Immunoassays
Steroid endocrinology
Aromatase inhibitors
In vitro
In vivo
Aromatase test sequence
Selectivity (ex vivo)
Aldosterone synthase inhibitors
In vivo
P450 17 inhibitors
In vitro
In vivo
Selectivity (in vitro)
CYP17 test sequence
5-alpha-reductase Inhibitors
In vitro
In vivo
GnRH agonists/antagonists
In vitro
In vivo
Pre-selection
GnRH test sequence
PK/PD relationship
Estrogens/anti-estrogens
Metabolic syndrome
Obesity
Diabetes type II
In vitro GLP-1 receptor assay
In vivo rat diabetes model
In vivo murine diabetes model
Food intake/weight gain studies
Cytotoxicity / Toxicology Screening
TOX-ESCAPE
Live-Cell Toxicology Screening Platform
Toxicology and Preclinical Development Unit
Flow Cytometry
Reactive oxygen species (ROS)
Apoptosis
Immunological effects
Membrane integrity
Cell cycle distribution
S-phase content
Regulatory Genotoxicity Test
Anti-Inflammatory Cytokine Response
In vitro cytotoxicity extrapolation for estimation of in vivo LD
50
Mitochondrial Transmembrane Potential
Intracellular Calcium Level
