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The following "Advanced Product Guide" is intended to aid you in finding appropriate solutions to your tasks and support your decision process. However, the final product should be considered as an estimate only that still might require further modification and optimization.

Items such as turnaround times, concentration ranges, and other experimental conditions might vary depending on your specific needs and need to be discussed with you in detail.

 In which Field are you interested?
 Development stage of your compound?
 GLP or Non-GLP?
 Which Test system do you prefer?
 How detailed do you expect the results?
 Which turnaround times do you need?
Showing 10 of 244 matches    -  
 
BA/ BE tests (rodents)
Readout: PK parameters
Assay set up: catheterised rats (n = 4 per galenical formulation) single compound i.v., p.o i.p., s.c., or i.m. application blood sampling at 7 time points each…
Analysis: LC-MS/MS
 
BBB -fast
Readout: % flux
Assay set up: Tris buffer, permeation across hydrophobic filter membrane treated with Brain Polar Lipid Extract post-experimental Lucifer Yellow assay included
Analysis: UV/Vis (chromophor required) or LC-MS/MS
 
Bioavailability (mice)
Readout: PK parameters
Assay set up: n = 3 per group one group per time point single compound i.v. single compound p.o., i.m., s.c., i.p. application blood sampling at 7 time points further…
Analysis: LC-MS/MS
 
Bioavailability (mice) - fast
Readout: PK parameters
Assay set up: n = 3 per group one group per time point single compound i.v. single compound p.o., i.m., s.c., i.p. application blood sampling at 7 time points further…
Analysis: LC-MS/MS
 
Bioavailability (mice) - serial blood sampling - fast
Readout: PK parameters
Assay set up: n = 2 x 4 single compound i.v. single compound p.o., i.m., s.c., i.p. application blood sampling at 4 time points by serial puncture of peripher veins…
Analysis: LC-MS/MS
 
Bioavailability (mice) - serial blood sampling
Readout: PK parameters
Assay set up: n = 2 x 4 single compound i.v. single compound p.o., i.m., s.c., i.p. application blood sampling at 4 time points by serial puncture of peripher veins…
Analysis: LC-MS/MS
 
Bioavailability (rats) - fast
Readout: PK parameters
Assay set up: catheterised animals (n = 3 per application route) single compound i.v. single compound p.o i.p., s.c., or i.m. application blood sampling at 7 time…
Analysis: LC-MS/MS
 
Bioavailability (rats, hamsters and guinea pigs)
Readout: PK parameters
Assay set up: catheterised animals (n = 3 per application route) single compound i.v. single compound p.o i.p., s.c., or i.m. application blood sampling at 7 time…
Analysis: LC-MS/MS
 
Caco2 permeation studies - Bidirectional (apical - basal, basal - apical)
Readout: Papp value (cm/sec); efflux ratio (Papp (B→A) / Papp (A→B)
Assay set up: 21-day Caco2 monolayers in Transwell
Analysis: UV/Vis (chromophor required) or LC-MS/MS
 
Caco2 permeation studies - Bidirectional (apical - basal, basal - apical) - fast
Readout: Papp value (cm/sec); efflux ratio (Papp (B→A) / Papp (A→B)
Assay set up: 21-day Caco2 monolayers in Transwell
Analysis: UV/Vis (chromophor required) or LC-MS/MS