Pharmacokinetics & in vivo Pharmacology

The assessment of early stage pharmacokinetic (PK) data of lead compounds in the drug development process is a prerequisite for successful animal pharmacology and toxicology studies. Valuable data generated in preclinically relevant species like rat or mouse enables the prediction of metabolism or PK in humans.

PK / PD Services

The data issued from blood samples are used to generate drug and/or metabolite concentration over time curves; urine and tissue samples to track the distribution. Using professional software, basic PK parameters (e.g. AUC, Cmax, tmax, elimination half-life, volume of distribution, clearance, oral bioavailability) are calculated and fundamental statistics performed.

Pharmacelsus also provides the PK in combination with pharmacodynamic parameters (PD) which describe the effect of drugs on targets (e.g. hormones or blood markers), organs or body weight in order to show dose dependency. Our experienced scientific staff is well-trained in the fields of male and female steroid endocrinology, as well as in metabolic diseases like diabetes and obesity.

Pharmacelsus plans and performs in vivo studies on the basis of reasonable scientific knowledge as well as in accordance with and supervised by animal welfare.