Target-based Bioassays

Pharmacelsus offers the development and performance of target-based bioassays on potency, efficacy and selectivity in vitro as well as in vivo.

Endocrinology, Diabetes & Obesity

Pharmacelsus has many years of experience in the field of steroid endocrinology.  Thus we can provide sound expertise for the in vitro and in vivo testing on potency, selectivity and efficacy to your projects on

Steroid endocrinology

• aromatase inhibitors for estrogen dependent diseases (PDF)
• CYP 17 inhibitors for androgen dependent diseases (PDF)
• LHRH antagonists for androgen or estrogen dependent diseases and (PDF)
• 5α - reductase inhibitors for androgen dependent diseases (PDF).

Benchmark your compounds with marketed drugs and benefit from the free Pharmacelsus consultancy for your preclinical endocrinology projects.

Bioassays in vitro & in vivo

In vitro assays are performed depending on the demands of our clients. Pharmacelsus offers cell-based assays using engineered cells or primary cell cultures. If required, ex vivo assays are performed after preparation of tissue fragments or isolation of cells from target tissues in order to identify compounds showing the desired effect.

Pharmacelsus' in-house facilities for animal experimentation allow the realisation of in vivo experiments on preclinical species like mouse and rat. Thus, several in vivo models have been established and characterized for a variety of endocrinological and metabolic diseases, being evaluated and performed in accordance with animal welfare legislation.

For individual research projects, Pharmacelsus develops and validates tailor-made in vitro and in vivo assays. In addition, Pharmacelsus also attaches greatest importance to support the clients in their research projects. Practically this means that each study will be designed individually according to the individual needs.